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Research Use Only. This product is intended exclusively for laboratory research purposes. Not for human consumption, medical use, or veterinary use. No dosing or administration instructions are provided.
Lysyl-Prolyl-Valine (KPV) | Research Grade | 10mg
$50.00
Synthetic tripeptide (α-MSH C-terminal fragment: Lys-Pro-Val) for laboratory research into NF-κB inflammatory signaling pathways and epithelial barrier function. ≥99% purity, HPLC-verified, with independent third-party Certificate of Analysis. For laboratory research use only. Not for human consumption.
50 in stock
≥99% PURE (HPLC)
THIRD-PARTY TESTED
COA INCLUDED
USA MANUFACTURED
THIRD-PARTY TESTED
COA INCLUDED
USA MANUFACTURED
Product Overview
Lysyl-Prolyl-Valine (KPV) is a synthetic tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH) consisting of the C-terminal three amino acids (Lys-Pro-Val). KPV serves as a biological research tool for investigating inflammatory signaling pathways, NF-κB pathway modulation, and epithelial barrier function in controlled laboratory settings.
Supplied as a lyophilized research reagent in a sterile vial at ≥99% purity. Every order is accompanied by an independent third-party verified Certificate of Analysis with a unique authentication key for direct lab verification.
Research Applications
KPV is intended for use in qualified laboratory research environments, including:
- NF-κB inflammatory signaling pathway modulation research
- Epithelial and mucosal barrier integrity studies
- Cytokine expression profiling in inflammatory cascade models
- Alpha-MSH receptor signaling and melanocortin pathway research
- Cellular stress response and signaling regulation studies
Mechanism of Action
KPV functions as the C-terminal tripeptide fragment of α-MSH, retaining key signaling properties of the parent hormone. In cellular assay models, KPV modulates the NF-κB signaling cascade by interfering with IκB kinase (IKK) phosphorylation, thereby reducing nuclear translocation of NF-κB and downstream expression of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6. KPV also influences epithelial barrier function through modulation of tight junction protein expression and cytoskeletal organization in mucosal and epithelial cell models. Unlike full-length α-MSH, KPV does not require melanocortin receptor (MC1R-MC5R) binding for its primary signaling effects, making it a valuable tool for distinguishing receptor-dependent and receptor-independent melanocortin pathway modulation in research settings.
Product Specifications
| Specification | Value |
|---|---|
| Compound | Lysyl-Prolyl-Valine (KPV) |
| Compound Name | H-Lys-Pro-Val-OH |
| CAS Number | 67727-97-3 |
| Amino Acid Sequence | Lys-Pro-Val (tripeptide, α-MSH C-terminal fragment) |
| One-Letter Code | KPV |
| Molecular Formula | C₁₆H₃₀N₄O₄ |
| Molecular Weight | 342.43 g/mol |
| Peptide Class | Synthetic tripeptide (α-MSH C-terminal fragment) |
| Purity | ≥99% (HPLC-verified) |
| Physical Form | Lyophilized powder |
| Appearance | White to off-white lyophilized powder |
| Net Content | 10mg |
| Manufacturing | USA-manufactured |
Quality & Testing
Every batch undergoes independent third-party laboratory testing to verify purity, identity, and quality. Each order includes:
- Certificate of Analysis (COA) with unique batch number
- Independent third-party verification key — verifiable directly through the testing laboratory’s online portal
- HPLC purity analysis
- Mass spectrometry identity confirmation
- Endotoxin and microbial contamination screening
“Trust is the most important compound in our catalog.” Every claim about purity, identity, and quality is independently verifiable — not just stated on a label.
Storage & Handling
- Product is supplied in a sterile vial — maintain sterility until use
- Store lyophilized material at -20°C upon receipt
- Protect from moisture and direct light
- Allow vial to equilibrate to room temperature before opening
- Handle in accordance with your institution’s laboratory safety protocols
- Use appropriate personal protective equipment when handling
Frequently Asked Questions
What is KPV?
KPV (Lysyl-Prolyl-Valine) is a synthetic tripeptide consisting of the C-terminal three amino acids of alpha-melanocyte-stimulating hormone (α-MSH). It is used as a research tool for studying inflammatory signaling pathways, particularly NF-κB pathway modulation, in controlled laboratory settings.
What is the CAS number for KPV?
The CAS registry number for Lysyl-Prolyl-Valine (KPV) is 67727-97-3.
What is the amino acid sequence of KPV?
KPV is a tripeptide with the sequence Lys-Pro-Val (K-P-V in single-letter amino acid code). It corresponds to residues 11-13 of α-MSH.
What is the mechanism of KPV?
KPV modulates the NF-κB inflammatory signaling cascade by interfering with IκB kinase (IKK) phosphorylation, reducing nuclear translocation of NF-κB and downstream pro-inflammatory cytokine expression. It also influences epithelial barrier function through tight junction protein modulation in cell culture models.
How is KPV supplied?
KPV is supplied as a lyophilized powder in a sterile vial at ≥99% purity. Each order includes a Certificate of Analysis with a unique verification key for independent lab verification.
Is KPV a peptide or a protein?
KPV is a tripeptide — a short peptide consisting of three amino acids (Lysine, Proline, Valine). It is not a protein. Peptides are short chains of amino acids, while proteins are longer, more complex structures.
This product is a laboratory research reagent and is not intended for human consumption, therapeutic use, diagnostic procedures, or veterinary applications. This product has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease. Researchers must ensure compliance with all applicable institutional, local, and federal regulations prior to use. Must be 21 or older to purchase.
| Weight | 0.1 lbs |
|---|---|
| Dimensions | 4 × 2 × 2 in |
| CAS Number | 67727-97-3 |
| Purity | ≥99% |
| Net Content | 10mg |
| Form | Lyophilized |
| Storage Temperature | -20°C |
Certificate of Analysis
COA data for the current batch is being processed. Please check back shortly or contact us with the lot number from your packaging.
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Product Disclaimer
For laboratory research use only. Not for human consumption, medical use, or veterinary use. These products have not been evaluated by the FDA. They are not intended to diagnose, treat, cure, or prevent any disease.
PepperCo Research products are manufactured and tested in accordance with industry standards. All products are accompanied by a Certificate of Analysis (COA) verifying purity and identity. Products are sold without instructions for use, administration, or preparation.
By purchasing, the buyer confirms they are 21 years of age or older and accepts full responsibility for the safe and proper handling of all materials in a laboratory research setting.
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