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Research Use Only. This product is intended exclusively for laboratory research purposes. Not for human consumption, medical use, or veterinary use. No dosing or administration instructions are provided.
Ipamorelin (GHSR Agonist) | Research Grade | 5mg
$64.99
Synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) and ghrelin receptor (GHSR) agonist designed for laboratory research into GHSR signaling pathways and GPCR activation mechanisms. ≥99% purity, HPLC-verified, with independent third-party Certificate of Analysis. For laboratory research use only. Not for human consumption.
50 in stock
≥99% PURE (HPLC)
THIRD-PARTY TESTED
COA INCLUDED
USA MANUFACTURED
THIRD-PARTY TESTED
COA INCLUDED
USA MANUFACTURED
Product Overview
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) that functions as a selective agonist of the growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor. As the first selective GHSR agonist identified, Ipamorelin serves as a biological research tool for investigating ghrelin receptor signaling pathways, G-protein coupled receptor (GPCR) activation mechanisms, and pituitary cell signaling in controlled laboratory settings.
Supplied as a lyophilized research reagent at ≥99% purity. Every order is accompanied by an independent third-party verified Certificate of Analysis with a unique authentication key for direct lab verification.
Research Applications
Ipamorelin is intended for use in qualified laboratory research environments, including:
- GHSR (ghrelin receptor) binding kinetics and agonist activity studies
- G-protein coupled receptor (GPCR) activation and intracellular signaling pathways
- Pituitary cell signaling and receptor pharmacology research
- Ghrelin receptor structure-activity relationship (SAR) characterization
- Neuropeptide receptor ligand binding and selectivity profiling
Mechanism of Action
Ipamorelin is a synthetic pentapeptide that functions as a selective, high-affinity agonist of the growth hormone secretagogue receptor (GHSR-1a), the same receptor activated by the endogenous peptide ghrelin. Upon binding to GHSR-1a — a G-protein coupled receptor (GPCR) expressed in pituitary and hypothalamic tissues — Ipamorelin activates Gαq/11 proteins, triggering phospholipase C (PLC) and intracellular calcium ([Ca²⁺]i) mobilization. This signaling cascade differs from cAMP-mediated pathways activated by GHRH receptor agonists, making Ipamorelin a valuable tool for studying GHSR-specific signal transduction and distinguishing between GHSR and GHRH receptor pathways in pituitary cell models.
Product Specifications
| Specification | Value |
|---|---|
| Compound | Ipamorelin |
| Compound Name | Aib-His-D-2-Nal-D-Phe-Lys-NH₂ |
| CAS Number | 170851-70-4 |
| Amino Acid Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH₂ (pentapeptide, C-terminal amide) |
| Molecular Formula | C₃₈H₄₉N₉O₅ |
| Molecular Weight | 711.9 g/mol |
| Peptide Class | Synthetic pentapeptide (GHSR agonist / ghrelin mimetic) |
| Purity | ≥99% (HPLC-verified) |
| Physical Form | Lyophilized powder |
| Appearance | White to off-white lyophilized powder |
| Net Content | 5mg |
| Manufacturing | USA-manufactured |
Quality & Testing
Every batch undergoes independent third-party laboratory testing to verify purity, identity, and quality. Each order includes:
- Certificate of Analysis (COA) with unique batch number
- Independent third-party verification key — verifiable directly through the testing laboratory’s online portal
- HPLC purity analysis
- Mass spectrometry identity confirmation
- Endotoxin and microbial contamination screening
“Trust is the most important compound in our catalog.” Every claim about purity, identity, and quality is independently verifiable — not just stated on a label.
Storage & Handling
- Product is supplied in a sterile vial — maintain sterility until use
- Store lyophilized material at -20°C upon receipt
- Protect from moisture and direct light
- Allow vial to equilibrate to room temperature before opening
- Handle in accordance with your institution’s laboratory safety protocols
- Use appropriate personal protective equipment when handling
Frequently Asked Questions
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) that functions as a selective agonist of the growth hormone secretagogue receptor (GHSR-1a), also known as the ghrelin receptor. It was the first selective GHSR agonist identified and serves as a research tool for studying ghrelin receptor signaling pathways and GPCR activation mechanisms.
What is the CAS number for Ipamorelin?
The CAS registry number for ipamorelin is 170851-70-4.
What is the amino acid sequence of Ipamorelin?
Ipamorelin is a pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂. Aib = alpha-aminoisobutyric acid, D-2-Nal = D-2-naphthylalanine, and the C-terminus is amidated.
What is the ghrelin receptor (GHSR)?
The growth hormone secretagogue receptor (GHSR-1a) is a G-protein coupled receptor (GPCR) activated by the endogenous peptide ghrelin. When activated, it couples to Gαq/11 proteins, triggering phospholipase C and intracellular calcium mobilization. GHSR is expressed in pituitary and hypothalamic tissues.
How should Ipamorelin be stored?
Store the lyophilized material at -20°C upon receipt. Protect from moisture and direct light. Allow the vial to equilibrate to room temperature before opening.
Is a Certificate of Analysis included?
Yes. Every order includes a batch-specific Certificate of Analysis with an independent third-party verification key, verifiable directly through the testing laboratory’s online portal.
For laboratory research use only. Not for human consumption.
This product is a laboratory research reagent and is not intended for human consumption, therapeutic use, diagnostic procedures, or veterinary applications. This product has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease. Researchers must ensure compliance with all applicable institutional, local, and federal regulations prior to use. Must be 21 or older to purchase.
| Weight | 0.1 lbs |
|---|---|
| Dimensions | 4 × 2 × 2 in |
| CAS Number | 170851-70-4 |
| Purity | >=99% |
| Net Content | 5mg |
| Form | Lyophilized |
| Storage Temperature | -20C |
Certificate of Analysis
COA data for the current batch is being processed. Please check back shortly or contact us with the lot number from your packaging.
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Product Disclaimer
For laboratory research use only. Not for human consumption, medical use, or veterinary use. These products have not been evaluated by the FDA. They are not intended to diagnose, treat, cure, or prevent any disease.
PepperCo Research products are manufactured and tested in accordance with industry standards. All products are accompanied by a Certificate of Analysis (COA) verifying purity and identity. Products are sold without instructions for use, administration, or preparation.
By purchasing, the buyer confirms they are 21 years of age or older and accepts full responsibility for the safe and proper handling of all materials in a laboratory research setting.
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