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Research Use Only. This product is intended exclusively for laboratory research purposes. Not for human consumption, medical use, or veterinary use. No dosing or administration instructions are provided.
MOTS-C (Mitochondrial-Derived Peptide) | Research Grade | 10mg
$94.99
Synthetic 16-amino-acid mitochondrial-derived peptide designed for laboratory research into mitochondrial signaling, AMPK pathway activation, and metabolic regulation. ≥99% purity, HPLC-verified, with independent third-party Certificate of Analysis. For laboratory research use only. Not for human consumption.
50 in stock
≥99% PURE (HPLC)
THIRD-PARTY TESTED
COA INCLUDED
USA MANUFACTURED
THIRD-PARTY TESTED
COA INCLUDED
USA MANUFACTURED
Product Overview
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a synthetic 16-amino-acid mitochondrial-derived peptide encoded within the 12S ribosomal RNA region of the mitochondrial genome. MOTS-C serves as a biological research tool for investigating mitochondrial retrograde signaling, AMPK pathway activation, and cellular metabolic regulation in controlled laboratory settings.
Supplied as a lyophilized research reagent at ≥99% purity. Every order is accompanied by an independent third-party verified Certificate of Analysis with a unique authentication key for direct lab verification.
Research Applications
MOTS-C is intended for use in qualified laboratory research environments, including:
- Mitochondrial signaling and retrograde communication research
- AMPK pathway activation and energy sensing studies
- Glucose transport and metabolic homeostasis models
- Nuclear translocation and gene expression regulation
- Cellular stress response and bioenergetics research
Mechanism of Action
MOTS-c functions as a mitochondria-to-nucleus retrograde signaling molecule. In response to cellular metabolic stress, MOTS-c regulates the folate cycle and purine biosynthesis, resulting in accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), which activates AMP-activated protein kinase (AMPK) — a central regulator of cellular energy homeostasis. Under metabolic or oxidative stress, MOTS-c translocates from the mitochondria and cytoplasm into the nucleus, where it interacts with chromatin and transcription factors including Nrf2/ARE pathways to regulate adaptive gene expression associated with cellular stress responses and glucose handling. Activated intracellular cascades also facilitate GLUT4 transporter translocation in cultured cell lines, modulating intracellular glucose utilization.
Product Specifications
| Specification | Value |
|---|---|
| Compound | MOTS-C (Mitochondrial-Derived Peptide) |
| CAS Number | 1627580-64-6 |
| Amino Acid Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| One-Letter Code | MRWQEMGYIFYPRKLR |
| Molecular Formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular Weight | 2174.62 g/mol |
| Purity | ≥99% (HPLC-verified) |
| Physical Form | Lyophilized powder |
| Appearance | White to off-white lyophilized powder |
| Net Content | 10mg |
| Manufacturing | USA-manufactured |
Quality & Testing
Every batch undergoes independent third-party laboratory testing to verify purity, identity, and quality. Each order includes:
- Certificate of Analysis (COA) with unique batch number
- Independent third-party verification key — verifiable directly through the testing laboratory’s online portal
- HPLC purity analysis
- Mass spectrometry identity confirmation
- Endotoxin and microbial contamination screening
“Trust is the most important compound in our catalog.” Every claim about purity, identity, and quality is independently verifiable — not just stated on a label.
Storage & Handling
- Product is supplied in a sterile vial — maintain sterility until use
- Store lyophilized material at -20°C upon receipt
- Protect from moisture and direct light
- Allow vial to equilibrate to room temperature before opening
- Handle in accordance with your institution’s laboratory safety protocols
- Use appropriate personal protective equipment when handling
Frequently Asked Questions
What is MOTS-C?
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino-acid peptide encoded within the mitochondrial genome. It functions as a retrograde signaling molecule, transmitting metabolic information from mitochondria to the nucleus in cellular research models.
What is the CAS number for MOTS-C?
The CAS registry number for MOTS-C is 1627580-64-6.
What does MOTS-C stand for?
MOTS-C stands for Mitochondrial Open Reading Frame of the 12S rRNA Type-C, reflecting its discovery as a small open reading frame encoded within the mitochondrial 12S ribosomal RNA gene.
How should MOTS-C be stored?
Store the lyophilized material at -20°C upon receipt. Protect from moisture and direct light. Allow the vial to equilibrate to room temperature before opening.
What is the AMPK pathway?
AMP-activated protein kinase (AMPK) is a central cellular energy sensor that regulates metabolic homeostasis. When activated, AMPK promotes ATP-producing pathways and inhibits ATP-consuming processes. MOTS-c activates AMPK through accumulation of AICAR in the folate-purine metabolic pathway in research models.
Is a Certificate of Analysis included?
Yes. Every order includes a batch-specific Certificate of Analysis with an independent third-party verification key, verifiable directly through the testing laboratory’s online portal.
For laboratory research use only. Not for human consumption.
This product is a laboratory research reagent and is not intended for human consumption, therapeutic use, diagnostic procedures, or veterinary applications. This product has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease. Researchers must ensure compliance with all applicable institutional, local, and federal regulations prior to use. Must be 21 or older to purchase.
| Weight | 0.1 lbs |
|---|---|
| Dimensions | 4 × 2 × 2 in |
| CAS Number | 1627580-64-6 |
| Purity | ≥99% |
| Net Content | 10mg |
| Form | Lyophilized |
| Storage Temperature | -20°C |
Certificate of Analysis
COA data for the current batch is being processed. Please check back shortly or contact us with the lot number from your packaging.
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Product Disclaimer
For laboratory research use only. Not for human consumption, medical use, or veterinary use. These products have not been evaluated by the FDA. They are not intended to diagnose, treat, cure, or prevent any disease.
PepperCo Research products are manufactured and tested in accordance with industry standards. All products are accompanied by a Certificate of Analysis (COA) verifying purity and identity. Products are sold without instructions for use, administration, or preparation.
By purchasing, the buyer confirms they are 21 years of age or older and accepts full responsibility for the safe and proper handling of all materials in a laboratory research setting.
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