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Research Use Only. This product is intended exclusively for laboratory research purposes. Not for human consumption, medical use, or veterinary use. No dosing or administration instructions are provided.
Pentadecapeptide PL 14736 | Research Grade | 10mg
$94.99
Synthetic pentadecapeptide (15 amino acids) designed for laboratory research into cellular migration, angiogenesis, and extracellular matrix signaling pathways. ≥99% purity, HPLC-verified, with independent third-party Certificate of Analysis. For laboratory research use only. Not for human consumption.
50 in stock
≥99% PURE (HPLC)
THIRD-PARTY TESTED
COA INCLUDED
USA MANUFACTURED
THIRD-PARTY TESTED
COA INCLUDED
USA MANUFACTURED
Product Overview
Pentadecapeptide PL 14736 is a synthetic pentadecapeptide consisting of 15 amino acids, originally identified in human gastric juice. Pentadecapeptide PL 14736 serves as a biological research tool for investigating cellular migration pathways, angiogenic signaling, focal adhesion dynamics, and extracellular matrix interactions in controlled laboratory settings.
Supplied as a lyophilized research reagent at ≥99% purity. Every order is accompanied by an independent third-party verified Certificate of Analysis with a unique authentication key for direct lab verification.
Research Applications
Pentadecapeptide PL 14736 is intended for use in qualified laboratory research environments, including:
- Angiogenesis and endothelial migration research
- Connective tissue engineering models
- Gastrointestinal epithelial barrier integrity studies
- Cellular migration and focal adhesion modulation
- Growth factor and receptor signaling regulation
Mechanism of Action
Pentadecapeptide PL 14736 modulates several interconnected signaling pathways in cellular and preclinical research models. In cultured tenocytes and fibroblasts, Pentadecapeptide PL 14736 upregulates phosphorylation of Focal Adhesion Kinase (FAK) and paxillin, promoting cytoskeletal assembly and cellular migration. In endothelial cell models, Pentadecapeptide PL 14736 increases expression of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), stimulating capillary-like tube formation and endothelial sprouting. Pentadecapeptide PL 14736 also modulates the endothelial nitric oxide (eNOS) system and downregulates NF-κB activation, reducing expression of pro-inflammatory cytokines including TNF-α and IL-6 in tissue assay models.
Product Specifications
| Specification | Value |
|---|---|
| Compound | Pentadecapeptide PL 14736 |
| CAS Number | 137525-51-0 |
| Amino Acid Sequence | H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH |
| One-Letter Code | GEPPPGKPADDAGLV |
| Molecular Formula | C₆₂H₉₈N₁₆O₂₂ |
| Molecular Weight | 1419.56 g/mol |
| Purity | ≥99% (HPLC-verified) |
| Physical Form | Lyophilized powder |
| Appearance | White to off-white lyophilized powder |
| Net Content | 10mg |
| Manufacturing | USA-manufactured |
Quality & Testing
Every batch undergoes independent third-party laboratory testing to verify purity, identity, and quality. Each order includes:
- Certificate of Analysis (COA) with unique batch number
- Independent third-party verification key — verifiable directly through the testing laboratory’s online portal
- HPLC purity analysis
- Mass spectrometry identity confirmation
- Endotoxin and microbial contamination screening
“Trust is the most important compound in our catalog.” Every claim about purity, identity, and quality is independently verifiable — not just stated on a label.
Storage & Handling
- Product is supplied in a sterile vial — maintain sterility until use
- Store lyophilized material at -20°C upon receipt
- Protect from moisture and direct light
- Allow vial to equilibrate to room temperature before opening
- Handle in accordance with your institution’s laboratory safety protocols
- Use appropriate personal protective equipment when handling
Frequently Asked Questions
What is Pentadecapeptide PL 14736?
Pentadecapeptide PL 14736 is a synthetic pentadecapeptide consisting of 15 amino acids. It is used as a laboratory research tool for investigating cellular migration, angiogenic signaling, and focal adhesion pathways in controlled in vitro and in vivo models.
What is the CAS number for Pentadecapeptide PL 14736?
The CAS registry number for Pentadecapeptide PL 14736 (free base) is 137525-51-0.
How many amino acids are in Pentadecapeptide PL 14736?
Pentadecapeptide PL 14736 is a pentadecapeptide containing 15 amino acids. The full sequence is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val.
How should Pentadecapeptide PL 14736 be stored?
Store the lyophilized material at -20°C upon receipt. Protect from moisture and direct light. Allow the vial to equilibrate to room temperature before opening.
What is the FAK-paxillin pathway?
The Focal Adhesion Kinase (FAK) and paxillin phosphorylation cascade is a cellular signaling pathway that regulates cytoskeletal assembly, focal adhesion formation, and cell migration. Pentadecapeptide PL 14736 has been shown to upregulate this pathway in cultured tenocytes and fibroblasts in published research.
Is a Certificate of Analysis included?
Yes. Every order includes a batch-specific Certificate of Analysis with an independent third-party verification key, verifiable directly through the testing laboratory’s online portal.
For laboratory research use only. Not for human consumption.
This product is a laboratory research reagent and is not intended for human consumption, therapeutic use, diagnostic procedures, or veterinary applications. This product has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease. Researchers must ensure compliance with all applicable institutional, local, and federal regulations prior to use. Must be 21 or older to purchase.
| Weight | 0.1 lbs |
|---|---|
| Dimensions | 4 × 2 × 2 in |
| CAS Number | 137525-51-0 |
| Purity | ≥99% |
| Net Content | 10mg |
| Form | Lyophilized |
| Storage Temperature | -20°C |
Certificate of Analysis
COA data for the current batch is being processed. Please check back shortly or contact us with the lot number from your packaging.
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Product Disclaimer
For laboratory research use only. Not for human consumption, medical use, or veterinary use. These products have not been evaluated by the FDA. They are not intended to diagnose, treat, cure, or prevent any disease.
PepperCo Research products are manufactured and tested in accordance with industry standards. All products are accompanied by a Certificate of Analysis (COA) verifying purity and identity. Products are sold without instructions for use, administration, or preparation.
By purchasing, the buyer confirms they are 21 years of age or older and accepts full responsibility for the safe and proper handling of all materials in a laboratory research setting.
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