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What Is Pentadecapeptide PL-14736?
PL-14736 is a synthetic pentadecapeptide (15 amino acid residues) developed by the PLIVA research organization in Croatia and also referenced in published literature under alternative designations including PL-10 and PLD-116. It has been studied in preclinical and in vitro models for connective tissue and mucosal response research, with research suggesting modulation of growth factor expression and extracellular matrix remodeling. PL-14736 is supplied as a lyophilized reagent in sterile vials for laboratory research use only.
| PL-14736 Key Facts | |
|---|---|
| Full Name | Pentadecapeptide PL-14736 |
| Also Known As | PDB, PL-10, PLD-116, PL-14736 |
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
| Amino Acid Count | 15 |
| Molecular Weight | ~1,419.55 g/mol |
| CAS Number | 137525-51-0 |
| Appearance | Lyophilized white powder in sterile vial |
| Purity | ≥99% (HPLC) |
| Storage | -20°C, protected from light and moisture |
What Is the Structure and Mechanism of PL-14736?
PL-14736 is a 15-residue peptide with the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. It was originally identified as a partial sequence of a body protection compound derived from human gastric juice protein. The peptide exhibits notable stability in aqueous research model systems, maintaining structural integrity across a range of pH conditions relevant to in vitro laboratory work.
In preclinical and cellular research models, PL-14736 has been reported to modulate several pathways associated with connective tissue response. Published in vitro studies indicate that the peptide upregulates growth hormone receptor expression in tendon fibroblasts at both the mRNA and protein levels, promotes fibroblast migration and survival, and may influence the expression of early growth response gene 1 (Egr-1) and other factors involved in extracellular matrix remodeling. These findings have been observed in cell culture and rat explant models, not in human subjects.
How Should PL-14736 Be Handled and Reconstituted?
PL-14736 is supplied as a lyophilized reagent in a sterile sealed vial and should be handled using standard laboratory practices for research peptides. The lyophilized powder should be stored at -20°C and protected from light and moisture until reconstitution. Under proper storage conditions, the peptide maintains integrity for the duration of the stated shelf life.
For reconstitution, the lyophilized reagent is dissolved in bacteriostatic water or an appropriate laboratory-grade buffer at the concentration required for the specific in vitro assay. The peptide is reported to be freely soluble in water at pH 7.0. Reconstituted solutions should be aliquoted to avoid repeated freeze-thaw cycles and stored frozen at -20°C. All handling should be performed under aseptic conditions appropriate for in vitro research applications.
- Storage (lyophilized): -20°C, sealed vial, protected from light
- Reconstitution solvent: Bacteriostatic water or laboratory buffer
- Solubility: Freely soluble in water at pH 7.0
- Post-reconstitution: Aliquot and store at -20°C; avoid repeated freeze-thaw cycles
- Handling: Aseptic technique appropriate for sterile in vitro research
How Is PL-14736 Quality Verified?
PepperCo Research supplies PL-14736 with a minimum purity of ≥99% as verified by High-Performance Liquid Chromatography (HPLC). Each batch is accompanied by a Certificate of Analysis (COA) documenting purity, peptide content, and mass verification. Quality testing follows standardized laboratory protocols to ensure consistency across production runs.
The quality verification process includes HPLC purity analysis, mass spectrometry confirmation of molecular weight, and residual solvent testing. Independent third-party testing is employed to verify batch-level quality, ensuring that the reagent meets the specifications required for reproducible in vitro research. Researchers should always review the COA accompanying each vial before use in laboratory applications.
- Purity: ≥99% verified by HPLC
- Mass verification: Confirmed by mass spectrometry
- Documentation: Certificate of Analysis provided with each batch
- Independent verification: Third-party laboratory testing
- Residual solvent testing: Performed per standard laboratory protocols
PL-14736 Research Reagent
Available as a lyophilized reagent in sterile vials, ≥99% purity, with Certificate of Analysis. For in vitro research and laboratory applications only.
Frequently Asked Questions
Is PL-14736 the same compound as PL-14736?
Yes. PL-14736 is the PLIVA development code for PL-14736, a synthetic pentadecapeptide also referenced as PL-10, PLD-116, and PL-14736 in the published literature. All designations refer to the same 15-amino-acid peptide sequence studied in preclinical connective tissue and mucosal response models.
What is the amino acid sequence of PL-14736?
The published sequence is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, comprising 15 amino acid residues with a molecular weight of approximately 1,419.55 g/mol. This sequence was originally derived from a partial sequence of a body protection compound found in human gastric juice.
What research areas has PL-14736 been studied in?
Published preclinical and in vitro studies have investigated PL-14736 in tendon and ligament repair, skin cellular migration and proliferation, gastric and intestinal mucosal tissue response, and extracellular matrix remodeling. Research models include rat tendon explant cultures, fibroblast migration assays, and thermal stress and tissue junction response studies.
How should PL-14736 reagent be stored and reconstituted for laboratory use?
Lyophilized PL-14736 reagent should be stored at -20°C in its original sealed vial. For reconstitution, bacteriostatic water or an appropriate laboratory buffer is used, and the reconstituted solution should be aliquoted and stored frozen to preserve peptide integrity for in vitro research applications.